Carboxylic acids and derivatives
Medchemexpress LLC Sumanirole maleate (U-95666E; PNU-95666E) | 179386-44-8 | 99.8% | C15H17N3O5 | 100 MG
Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. It plays an important role in the research of Parkinson's disease and restless leg syndrome.
- Highly selective D2 receptor full agonist
- ED50 of about 46 nM
- Valuable tool compound for basic research
- Identifies neurobiological mechanisms based on dopamine D2-linked mechanism of action
Medchemexpress LLC Sumanirole maleate | 179386-44-8 | 99.8% | C15H17N3O5 | 1 ML
Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of approximately 46 nM. It is important in the research of Parkinson's disease and restless leg syndrome. Sumanirole serves as a valuable tool compound for basic research to identify neurobiological mechanisms based on a dopamine D2-linked mechanism of action.
- Highly selective D2 receptor full agonist
- ED50 of approximately 46 nM
- Important in research of Parkinson's disease
- Important in research of restless leg syndrome
- Valuable tool compound for basic research
Selleck Chemical LLC Indacaterol Maleate S3083-5mg
Indacaterol (QAB149) is an ultra-long-acting -adrenoceptor agonist with pKi of 7 36 for 1-adrenoceptor and pKi of 5 48 for 2-adrenoceptor
Medchemexpress LLC Cinepazide Maleate | 26328-04-1 | 99.7% | C26H35N3O9 | 25 MG
Cinepazide Maleate is a piperazine derivative that acts as a weak calcium channel blocker and a potent vasodilator. It is utilized in research for cerebrovascular diseases, including ischemic stroke and brain infarct.
- Acts as a weak calcium channel blocker
- Potent vasodilator
- Used for research on cerebrovascular diseases
- Suitable for ischemic stroke and brain infarct research
- For research use only
Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 25 MG
Neratinib maleate is an orally available, irreversible, and highly selective inhibitor of HER2 and EGFR, intended for research use only. It inhibits the proliferation of cell lines expressing high levels of HER-2 and demonstrates anticancer activities in vivo by reducing tumor growth in a dose-dependent manner in various xenografts.
- Orally available, irreversible, highly selective HER2 and EGFR inhibitor.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase.
- Inhibits MAPK and Akt phosphorylation.
- Down-regulates cyclin D1 levels and induces p27.
- Shows anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
Medchemexpress LLC Omigapil maleate | 200189-97-5 | 99.8% | 391.42 | 25 MG
Omigapil maleate (CGP3466B) is an orally active GAPDH nitrosylation inhibitor that abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. It has potential for Alzheimer's disease research and is also an apoptosis inhibitor. Additionally, it can be used for congenital muscular dystrophy (CMD) research.
- Orally active GAPDH nitrosylation inhibitor.
- Abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.
- Potential for Alzheimer's disease research.
- Apoptosis inhibitor.
- Can be used for congenital muscular dystrophy (CMD) research.
- Click chemistry reagent with an alkyne group for CuAAc reactions.
TARGETMOL CHEMICALS INC DIZOCILPINE MALEATE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. purity: 99%
Medchemexpress LLC BRL-44408 maleate | 681806-46-2 | MFCD02262218 | 99.0% | 331.37 g/mol | C17H21N3O4 | 5 MG
BRL-44408 maleate is a small-molecule α2A-adrenoceptor antagonist used in preclinical pharmacology research. It shows high affinity for α2A receptors (Ki ≈ 8.5 nM) and has demonstrated antidepressant and analgesic activity in animal studies.
- Selective α2A-adrenoceptor antagonist with Ki ≈ 8.5 nM.
- Demonstrates antidepressant and analgesic activity in preclinical models.
- Solid, light brown to brown appearance.
- Molecular weight 331.37 g/mol; formula C17H21N3O4.
- Purity 99.0% (HPLC).
- Soluble in DMSO at 30 mg/mL; may require ultrasonic and warming.
- Store sealed, away from moisture at -20 °C; in solution, store at -80 °C for long-term stability.
(OCC)OCC | 25g | 491684614](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502422592.JPG-250.jpg)
eMolecules 5089-70-3 | (3-Chloropropyl)triethoxysilane | Ambeed | MFCD00018985 | 240.800 | C9H21ClO3Si | 97.000 | CCO[Si](CCCCl)(OCC)OCC | 25g | 491684614
(3-Chloropropyl)triethoxysilane | Ambeed | 5089-70-3 | MFCD00018985 | 240.800 | C9H21ClO3Si | 97.000 | CCO[Si](CCCCl)(OCC)OCC | 25g | 491684614
eMolecules 922-67-8 | Methyl propiolate | Ambeed | MFCD00008572 | 84.074 | C4H4O2 | 98.000 | COC(=O)C#C | 25g | 552720844
Methyl propiolate | Ambeed | 922-67-8 | MFCD00008572 | 84.074 | C4H4O2 | 98.000 | COC(=O)C#C | 25g | 552720844
(C)Oc1ccc(F)c(c1)B(O)O | 100mg | 717401769](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502431297.PNG-250.jpg)
eMolecules 1150114-53-6 | (5-((tert-Butyldimethylsilyl)oxy)-2-fluorophenyl)boronic acid | Ambeed | MFCD11855846 | 270.180 | C12H20BFO3Si | 98.000 | CC(C)(C)[Si](C)(C)Oc1ccc(F)c(c1)B(O)O | 100mg | 717401769
(5-((tert-Butyldimethylsilyl)oxy)-2-fluorophenyl)boronic acid | Ambeed | 1150114-53-6 | MFCD11855846 | 270.180 | C12H20BFO3Si | 98.000 | CC(C)(C)[Si](C)(C)Oc1ccc(F)c(c1)B(O)O | 100mg | 717401769
Medchemexpress LLC IMMH-010 maleate | 2541982-47-0 | 99.8% | 756.04 | 1 MG
IMMH-010 maleate is a prodrug that serves as a novel PD-L1 inhibitor, exhibiting potential antitumor activity for the treatment of neurological disorders and advanced malignant solid tumors. It is rapidly converted to its active form, YPD-29B, following oral administration. IMMH-010 maleate is poised for advancing research in the field of PD-L1 inhibitors and related therapeutic applications.
- Novel PD-L1 inhibitor
- Exhibits potential antitumor activity for neurological disorders and advanced malignant solid tumors
- Prodrug that rapidly converts to its active form, YPD-29B, following oral administration
- Poised for advancing research in the field of PD-L1 inhibitors and related therapeutic applications
Medchemexpress LLC U-99194 maleate | 234757-41-6 | 99.2% | 10 MG
U-99194 maleate is a selective, potent dopamine D3 receptor antagonist with a Ki of 160 nM. It inhibits the activation of the D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. This compound can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
- Selective, potent dopamine D3 receptor antagonist
- Inhibits activation of D3 receptor
- Abrogates IPSC-suppressive effect of D3 agonist PD 128907 in rat hippocampal slices
- Significantly suppresses nicotine-induced tremor in mice
Medchemexpress LLC Lisuride maleate | 19875-60-6 | 454.52 | 1 ML
Lisuride maleate is a potent dopamine agonist that directly acts on dopaminergic receptors. This ergot derivative can release premenstrual mastalgia without significant side effects. Research indicates its in vivo potency, demonstrating effectiveness in antagonizing motor depression and hypothermia. It has also been involved in clinical trials for conditions such as Parkinson's Disease, Restless Legs Syndrome, and Cocaine-Related Disorders.
- Potent dopamine agonist
- Releases premenstrual mastalgia
- Antagonizes motor depression and hypothermia
- Used in clinical trials for neurological disorders
- Stable under recommended storage conditions
- Soluble in various solvents for research applications